4-Nitrobenzyl Hydrogen Malonate CAS 77359-11-6

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Product Name:4-Nitrobenzyl hydrogen malonate CAS 77359-11-6

 

Malonic acid mono-4-nitrobenzyl ester;

 

Assay: 99%+

Melting point:109 degree

Boiling point::455.8±30.0 degree

Density:1.447±0.06g/cm³

Pka:2.49±0.32

 

4-Nitrobenzyl hydrogen malonate is a reagent used in the synthesis of (±)-thienamycin, a -Lactam antibiotics. Also, it is useful for chiral key intermediate of carbapenem syntheses.

Preparation of mono-4-nitrobenzyl malonate:

In a flame-dried 150 mL pressure tube under argon, add 5.00 g (34.7 mmol) of Meldrum's acid and 40 mL of anhydrous MeCN.

Add 5.58 g (36.4 mmol) of p-nitrobenzyl alcohol to the resulting solution.

Purify the residue using column chromatography with a 55/45 hexane/EtOAc mixture.

The resulting product is mono-4-nitrobenzyl malonate with a yield of 87%.

 

 

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